abstract：:Thirty-six patients (21 male, 15 female) with ductal pancreatic cancer were treated with the long-acting synthetic luteinizing hormone releasing hormone (LH-RH) analogue buserelin. All patients had advanced tumor stages (stage II: 7 patients; stage III: 11 patients; stage IV: 18 patients). A monthly follow-up includin...

journal_title：Pancreas

authors： Friess H,Büchler M,Krüger M,Beger HG

更新日期：1992-01-01 00:00:00

abstract：:This study was undertaken to determine the involvement of endogenous cholecystokinin (CCK) in the regeneration of pancreatic tissue after cerulein-induced acute pancreatitis treated by the CCK receptor antagonist L364,718. Acute pancreatitis was induced in rats by s.c. injections of cerulein in gelatin (12 micrograms/...

journal_title：Pancreas

authors： Jurkowska G,Grondin G,Morisset J

更新日期：1992-01-01 00:00:00

abstract：:In this study, we performed a detailed analysis of the immunoreactive (IR) patterns and tissue distribution of vasoactive intestinal polypeptide (VIP), neuropeptide Y (NPY), and gastrin-releasing peptide (GRP) in the feline pancreas by means of immunohistochemical and radioimmunological techniques. Immunoreactivity fo...

journal_title：Pancreas

authors： De Giorgio R,Sternini C,Brecha NC,Widdison AL,Karanjia ND,Reber HA,Go VL

更新日期：1992-01-01 00:00:00

abstract：:The influence of the neuropeptide galanin, present in intrapancreatic nerve endings, on the endocrine pancreas is well known. The most potent effect of galanin is inhibition of insulin release. Little is known of its effect on the exocrine pancreas. Whether galanin plays a role in the regulation of exocrine pancreatic...

journal_title：Pancreas

authors： Rünzi M,Müller MK,Schmid P,von Schönfeld J,Goebell H

更新日期：1992-01-01 00:00:00

abstract：:Islet amyloid polypeptide (IAPP) has been recently identified as the principal constituent of amyloid deposits in pancreatic islets of patients with type 2 (non-insulin-dependent) diabetes mellitus and causes insulin resistance in some target cells. In addition, glucose-induced insulin secretion is inhibited by IAPP. ...

journal_title：Pancreas

authors： Chuang LM,Wu HP,Jou TS,Tai TY,Lin BJ

更新日期：1992-01-01 00:00:00

abstract：:The effects of a specific cholecystokinin (CCK) receptor antagonist (L364,718) and a gastrin receptor antagonist (L365,260) on gastrin-releasing peptide-10 (GRP-10)-stimulated pancreatic secretion were investigated in the anesthetized rat. GRP-10 stimulated pancreatic exocrine secretion in a dose-dependent manner. A d...

journal_title：Pancreas

authors： Terashima H,Debas HT,Bunnett NW

更新日期：1992-01-01 00:00:00

abstract：:Ornithine decarboxylase (ODC) is the rate-limiting enzyme in polyamine biosynthesis. We examined circadian variations in pancreatic ODC activity and time-course effects of caerulein in fed and fasted rats. Significant circadian variations in amount of ODC activity were observed. The highest values were obtained during...

journal_title：Pancreas

authors： Langlois A,Morisset J

更新日期：1991-09-01 00:00:00

abstract：:The effect on endogenous beta-endorphins of a new synthetic protease inhibitor was studied in acute pancreatitis. Pancreatitis was induced by the injection of autologous bile mixed with trypsin into the main pancreatic duct after ligation of the accessory duct. Plasma beta-endorphin concentrations and cardiovascular f...

journal_title：Pancreas

authors： Satake K,Hiura A,Ha SS,Nishiwaki H,Umeyama K

更新日期：1991-07-01 00:00:00

abstract：:Radical pancreaticoduodenectomy was performed for cancer of the head of the pancreas in a 65-year-old male patient with congenital celiac occlusion. Preoperative angiography revealed that the arterial flow to the liver, spleen, and stomach was supplied via the pancreaticoduodenal arcade and that the dorsal pancreatic ...

journal_title：Pancreas

authors： Manabe T,Baba N,Setoyama H,Ohshio G,Tobe T

更新日期：1991-05-01 00:00:00

abstract：:The peptide hormones neurotensin (NT) and cholecystokinin (CCK) are commonly attributed with a physiological role in the stimulation of exocrine pancreatic secretion. However, on the other hand, little is known about the effect of diminished exocrine pancreatic function and of the resulting maldigestion on postprandia...

journal_title：Pancreas

authors： Nustede R,Köhler H,Fölsch UR,Schafmayer A

更新日期：1991-05-01 00:00:00

abstract：:Acute pancreatic duct obstruction causes hyperamylasemia and mild pancreatic inflammation. We hypothesized that bile exclusion from the gut, which stimulates pancreatic secretion, exacerbates acute pancreatitis caused by pancreatic duct obstruction. Rats were surgically prepared with gastric, duodenal, bile, and pancr...

journal_title：Pancreas

authors： Murayama KM,Drew JB,Yokoo H,Joehl RJ

更新日期：1991-03-01 00:00:00

abstract：:Leucine is known to enhance insulin secretion from islets of Langerhans, and insulin promotes leucine uptake in peripheral tissues. The present studies were designed to elucidate the effects of leucine on glucose responsiveness and stimulus secretion coupling in mouse islets of Langerhans. The effects of 20 mM leucine...

journal_title：Pancreas

authors： Brouwer AE,Carroll PB,Atwater IJ

更新日期：1991-03-01 00:00:00

abstract：:Pretreatment of rat pancreatic acini with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) for 5 or 10 min reduced cytosolic free calcium and amylase secretion stimulated by submaximal concentration (10(-6) M) of carbachol in a dose-dependent manner. 10(-7) M TPA inhibited initial amylase secretion and had no effect on sus...

journal_title：Pancreas

authors： Arita Y,Kimura T,Ogami Y,Nawata H

更新日期：1991-01-01 00:00:00

abstract：:Neonatal rats treated with streptozotocin on day 5 after birth (n5-STZ model) exhibited, when fully grown, a frank basal hyperglycemia (17.4 +/- 0.7 vs. 6.6 +/- 0.2 mmol/L in nondiabetic rats), a specific failure of glucose-induced insulin release, and hyperresponse to arginine. To investigate whether or not chronic c...

journal_title：Pancreas

authors： Serradas P,Bailbé D,Blondel O,Portha B

更新日期：1991-01-01 00:00:00

abstract：:Stimulation of intact rat pancreatic acini with cholecystokinin (CCK) enhances the phosphorylation of the ribosomal protein S6 in a dose-dependent manner with half maximal stimulation at 40 pM and maximal stimulation at 1 nM CCK octapeptide. Soluble cellular extracts contained S6 kinase activity assayed using purified...

journal_title：Pancreas

authors： Sung CK,Williams JA

更新日期：1990-11-01 00:00:00

abstract：:The effects of manganese (Mn2+) on phosphorylation activity in the rat pancreas were examined in an in vitro phosphorylation assay and by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) of endogenous proteins. Several histones were phosphorylated in the presence of pancreatic supernatant obtained ...

journal_title：Pancreas

authors： Brockenbrough JS,Korc M

更新日期：1990-09-01 00:00:00

abstract：:Changes in pancreatic growth and in mRNA concentrations in rat pancreas were monitored by dot-blot hybridization with cloned cDNAs of rat amylase, chymotrypsinogen B, proinsulin I, and actin during the pre- and postnatal period in the rat. Wistar rats were killed at the 18th day of gestation and at the 1st, 10th, 20th...

journal_title：Pancreas

authors： Iovanna JL,Dusetti N,Cadenas B,Calvo EL

更新日期：1990-07-01 00:00:00

abstract：:Although fat accumulation in acinar cells is the earliest histopathological change in the pancreas of patients and experimental animals, there are few long-term studies regarding lipid composition of the pancreas in alcoholism. In the present study, female Sprague-Dawley rats were divided into three groups each fed Wa...

journal_title：Pancreas

authors： Simsek H,Singh M

更新日期：1990-07-01 00:00:00

abstract：:To confirm the accuracy of guided percutaneous aspiration (GPA) in distinguishing sterile from infected pancreatic necrosis, we have performed Brown-Brenn tissue Gram stains on pancreatic and peripancreatic necrotic tissue removed operatively in 15 patients. In eight patients judged to have sterile necrosis on the bas...

journal_title：Pancreas

authors： Banks PA,Gerzof SG,Chong FK,Worthington MG,Doos WG,Sullivan JG,Johnson WC

更新日期：1990-05-01 00:00:00

abstract：:Exocrine proteins contained in human pancreatic juice were analyzed by reversed-phase high performance liquid chromatography (RP-HPLC). Pancreatic juice was saved by endoscopic retrograde cannulation of the main pancreatic duct in 17 persons: 12 without pancreatic disease, 3 patients suffering from recurrent acute pan...

journal_title：Pancreas

authors： Göke B,Keim V,Dagorn JC,Arnold R,Adler G

更新日期：1990-05-01 00:00:00

abstract：:The in vitro incorporation of [35S]cysteine into lipase, colipase, amylase, procarboxypeptidase A and B, and the serine proteases and total proteins was studied in pancreatic lobules isolated from normal and diabetic rats with or without insulin treatment. The incorporation of [35S]cysteine into total proteins was 65%...

journal_title：Pancreas

authors： Duan RD,Erlanson-Albertsson C

更新日期：1990-03-01 00:00:00

abstract：:This study was performed to assess the effects of misoprostol, a synthetic prostaglandin E1 analog, on cerulein-induced pancreatitis. Per group of 10 each, male Wistar rats received either cerulein (2.5 micrograms/kg/h subcutaneously), cerulein and misoprostol (500 micrograms/kg intraperitoneally at 0 and 4 h), or sal...

journal_title：Pancreas

authors： Buscail L,Bussenot I,Bouisson M,Sénégas-Balas F,Bertrand C,Balas D,Vaysse N,Ribet A

更新日期：1990-03-01 00:00:00

abstract：:A case of relapsing pancreatitis in a young man is presented. Stenosis of the main duct and cystic lesions of the tail of the pancreas were shown by ultrasonography, CT scan, and endoscopic retrograde cholangiopancreatography (ERCP). After a wrong diagnosis of cancer, the pathological examination demonstrated an eosin...

journal_title：Pancreas

authors： Bastid C,Sahel J,Choux R,Payan MJ,Sarles H

更新日期：1990-01-01 00:00:00

abstract：:Pretreatment of rat pancreatic acini with phorbol 12-myristate, 13-acetate (PMA), a protein kinase C (PK-C) activator, caused the desensitization of carbamylcholine (CBC)-induced amylase release in a concentration- and time-dependent fashion. The less potent phorbol-12, 13-dibutyrate (PDBu) also provoked a desensitiza...

journal_title：Pancreas

authors： Blanchard LM,Paquette B,Larose L,Morisset J

更新日期：1990-01-01 00:00:00

abstract：:In a patient with pancreatic cancer, an arterial anomaly was observed that apparently consisted of the congenital absence of the celiac axis and the replacement of the pancreaticoduodenal arcade by an anomalous vessel. The complete or near-complete arterial flow to the liver and spleen depended upon this anomalous pre...

journal_title：Pancreas

authors： Howard JM,Woldenberg LS,Conover SV

更新日期：1989-01-01 00:00:00

abstract：:The accuracies of assays of serum CA 19-9 and elastase 1 in the diagnosis of pancreatic carcinoma were investigated by the cutoff method and discriminant analysis of data on 98 patients with pancreatitis, 65 patients with pancreatic carcinoma, 107 patients with benign diseases of other organs, and 108 patients with ca...

journal_title：Pancreas

authors： Yamamura H,Tatsuta M,Ito M,Iishi H,Noguchi S,Okuda S,Yoshida M

更新日期：1989-01-01 00:00:00

abstract：:The application of a commercially available enzyme immunoassay method for the determination of lipase concentration in human duodenal fluid is reported. Variations in the test procedure have been investigated. A sample incubation and a conjugate incubation of 1 h at 37 degrees C are necessary. There is substantial agr...

journal_title：Pancreas

authors： Hafkenscheid JC,Hessels M,Kerstens PJ,Lamers CB

更新日期：1989-01-01 00:00:00

abstract：:Stimulation of the exocrine pancreas is one of the biological effects attributed to the tridecapeptide neurotensin (NT). Only the C-terminal 8-13 fragment with its extremely short plasma half-life in the peripheral circulation was considered to be necessary for biological activity. The N-terminal fragments that are de...

journal_title：Pancreas

authors： Nustede R,Köhler H,Pfannkuche A,Fölsch UR,Schafmayer A

更新日期：1989-01-01 00:00:00

abstract：:Measurement of pancreatic blood flow (PBF) is technically demanding. Although radiolabeled microspheres are considered the "gold standard" for PBF assessment, they have practical limitations. In the current study, H2 and xenon-133 gas clearance techniques were adapted to PBF measurement and compared to radiolabeled mi...

journal_title：Pancreas

authors： DeMar AR,Graham LS,Lake R,Fink AS

更新日期：1989-01-01 00:00:00

abstract：:Five human pancreatic carcinoma cell lines were screened for the presence of muscarinic cholinergic receptors (mAChRs), using [3H]N-methylscopolamine ([3H]NMS). T3M4 and COLO-357 cells exhibited specific, high-affinity binding to mAChRs. A small amount of [3H]NMS also bound in PANCI and ASPC-I cells, but not in MIA Pa...

journal_title：Pancreas

authors： Ackerman MS,Roeske WR,Heck RJ,Korc M

更新日期：1989-01-01 00:00:00

abstract：:The involvement of endogenous prostaglandins (PGs) in pancreatic endocrine and exocrine secretion was investigated, using the isolated and perfused dog pancreas. Spontaneous production of both PGE2 and 6-keto-PGF1 alpha was recorded in venous effluent. Prostaglandin production increased following stimulation with both...

journal_title：Pancreas

authors： Kuroda T,Sodeyama H,Hanazaki K,Horigome N,Kajikawa S,Yamagishi K,Horiuchi A,Iwatsuki K,Chiba S,Homma T

更新日期：1989-01-01 00:00:00

abstract：:The glycolytic inhibitor, 2-deoxy-D-glucose (2-DG), inhibits growth of some cancers. alpha-Difluoromethylornithine (DFMO) is an irreversible inhibitor of ornithine decarboxylase, the rate-limiting enzyme in polyamine biosynthesis. We and others have previously shown that DFMO inhibits cancer growth in a number of mode...

journal_title：Pancreas

authors： Saydjari R,Alexander RW,Barranco SC,Townsend CM Jr,Thompson JC

更新日期：1989-01-01 00:00:00

abstract：:A 66-year-old patient had been admitted four times for recurrent episodes of acute pancreatitis. At each time, elevated serum calcium levels, between 13.5-14.5 mg/dl, were found. Surgical drainage of necrotic pancreatic tissue had to be done on one occasion. Extensive investigations failed to disclose any conventional...

journal_title：Pancreas

authors： Waele BD,Smitz J,Willems G

更新日期：1989-01-01 00:00:00

abstract：:Human pure pancreatic juice (PPJ) and serum were analyzed for free fatty acids (FFAs) to study whether the damage to pancreatic cell membranes in pancreatitis is reflected as abnormal FFAs concentration and composition. Patients consisted of 13 normal controls, 7 patients with acute pancreatitis (AP) in remission, and...

journal_title：Pancreas

authors： Miyake H,Harada H,Ochi K,Oka H,Ishibashi T,Kimura I

更新日期：1988-01-01 00:00:00

abstract：:In recent studies performed on pancreatic stones from patients with alcoholic pancreatitis, a novel secretory protein was identified: the pancreatic stone protein (PSP Mr 14,000). This protein suppresses CaCO3 precipitation, and could therefore stabilize normally supersaturated pancreatic juice. Crystallographic analy...

journal_title：Pancreas

authors： Montalto G,Multigner L,Sarles H,De Caro A

更新日期：1988-01-01 00:00:00

abstract：:A new technique to obstruct the pancreatic ducts was developed by injecting zein solution into the common bile duct of the rat. Four weeks after the injection, the fate of the endocrine pancreas was investigated by studying (a) pancreatic content of four pancreatic hormones, (b) histology and immunohistochemistry of t...

journal_title：Pancreas

authors： Tomita T,Rhodes J,Falscroft J,Doull V,Kimmel JR,Pollock HG

更新日期：1988-01-01 00:00:00

abstract：:Periodic oscillation of insulin and glucagon by isolated mice islets has been studied. Pulsatile secretion of insulin and glucagon was observed at all glucose concentrations tested. The frequency of oscillation per 20 min for glucagon was 5.0 +/- 0.26 and for insulin 4.0 +/- 0.26 (n = 6), approximating to periodicitie...

journal_title：Pancreas

authors： Opara EC,Atwater I,Go VL

更新日期：1988-01-01 00:00:00

abstract：:Previous studies have shown that the DU-PAN-2 antigen is elevated in approximately 70% of serum samples obtained from pancreatic adenocarcinoma patients, and within the normal range (less than 400 U/ml) in 99% of normal subjects. In this study, the DU-PAN-2 antigen level of the serum and pancreatic ductal fluid in pat...

journal_title：Pancreas

authors： Mahvi DM,Seigler HF,Meyers WC,Kalthoff H,Schmiegel WH,Metzgar RS

更新日期：1988-01-01 00:00:00

abstract：:We report a case of severe acute pancreatitis associated with both gastric and abdominal wall infarction. The early skin changes on the anterior abdominal wall could be confused with Grey-Turner's sign. ...

journal_title：Pancreas

authors： Scholefield JH,Goodman AJ,Morgan WP

更新日期：1988-01-01 00:00:00

abstract：:Chemoprevention by a synthetic retinoid, selenium, and these agents in combination during the postinitiation stages of carcinogenesis induced in rats by azaserine was evaluated. Male Lewis rats were given three weekly injections of 30 mg/kg azaserine while being fed a purified diet. One week after completion of carcin...

journal_title：Pancreas

authors： Curphey TJ,Kuhlmann ET,Roebuck BD,Longnecker DS

更新日期：1988-01-01 00:00:00